A postdoctoral fellowship is available in the laboratory of Dr. John Crispino in the Division of Experimental Hematology. Dr. Crispino’s laboratory studies the biology of normal and malignant hematopoiesis with an emphasis on the factors that drive progression of benign disorders to acute leukemia. Research in the lab ranges from the basic science of transcription to translational research aimed at developing treatments for blood disorders. A current major focus of the lab is to understand the increased risk of leukemia …
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The Abraham lab studies gene expression-regulation mechanisms in healthy and diseased mammalian cells. We are recruiting computational biologists to collaboratively develop computational tools and frameworks to analyze high-throughput sequencing (-omics) data. We build analytical software pipelines to find answers to biological questions about gene regulation in big datasets, usually from applied sequencing experiments like ChIP-Seq, RNA-Seq, and Hi-ChIP. Our interests center on enhancers and super-enhancers. Specifically, we seek to understand how these regulatory elements establish gene expression programs in healthy …
The Chen Lab studies: i) Chemical modulation of transcription; ii) Signal crosstalk among transcription factors; and iii) Selective inhibition of highly homologous enzymes. We take a hypothesis-driven and technology-enabled multidisciplinary approach to develop chemical probes and investigate biological mechanisms. Particularly we use the promiscuous xenobiotic nuclear receptors (PXR and CAR) as models to investigate the transcription networks that regulate therapeutic responses. PXR and CAR regulate the detoxification system (e.g., by transcriptionally controlling CYP3A4 and CYP3A5—drug-metabolizing enzymes that metabolize more than …
The Rosch lab is looking for a postdoctoral scientist with an interest in host-pathogen interactions and/or antibiotic resistance. We are I looking for candidate with a PhD in Microbiology, Molecular Biology, or related field. Ideal candidates will have proven expertise in bacterial genetics, molecular techniques, and/or pathogenesis studies and excellent communication skills. Individuals should have the ability to work collaboratively in a fast-paced research environment. Research will focus on understanding the genetic basis of antibiotic resistance in Streptococcus pneumoniae as …
The Blanchard laboratory in the Department of Structural Biology is seeking a highly motivated Postdoctoral Fellow with experience in protein and membrane protein biochemistry to join a newly funded GPCR collaborative project to investigate the structural dynamics of GPCRs and their signaling partners using biophysical methods, including single-molecule FRET (smFRET). The ideal candidate would be a recent PhD graduate with a demonstrated capability to propose new hypotheses based on scientific literature, design experiments, and interpret results in a mechanistic framework. …
A postdoctoral position is available in the Derecka Lab in the Department of Hematology at St. Jude Children’s Research Hospital to study transcriptional regulation of the bone marrow niche. The major research goal of our group is to gain mechanistic insights into cellular cross communication between bone marrow microenvironment and hematopoietic compartment, in steady state and pathophysiological conditions. You will have the opportunity to develop new exciting projects involving changes of bone marrow microenvironment and its impact on aging blood …
A postdoctoral research fellowship is available in the laboratory of Dr. Jeffrey M. Rybak in the Department of Pharmacy and Pharmaceutical Sciences at St. Jude Children’s Research Hospital. The long-term goal of the Rybak lab is to advance the treatment of children with invasive fungal infections by developing new therapeutic strategies to overcome difficult-to-treat fungal pathogens.Research in the Rybak lab broadly has three areas of emphasis:• Developing and refining molecular and genetic tools for difficult-to-treat and currently understudied fungal pathogens …
The Cancer Stem Cell Dynamics laboratory of Dirk Loeffler is seeking exceptionally motivated and ambitious candidates for a Postdoctoral Position, starting Jan. 1st, 2024, or the earliest date thereafter. If you are curious, creative, and goal-oriented with a keen interest in science, technology, and data this is the right position for you!We study the genetic and epigenetic changes in blood stem and progenitor cells during hematopoietic diseases and aging. The ideal candidate is curious, self-motivated, independent, hard-working, and has excellent …
As a part of the Center of Excellence for Data-Driven Discovery in the Department of Structural Biology at St. Jude Children’s Research Hospital, the Babu Group seeks a highly driven, full-time Postdoctoral Research Associate to develop computational pipelines and machine learning approaches to quantify obesity risk and predict its effects by leveraging large-scale omics data. This position requires relocation to Memphis, TN. When possible, it will involve travel for collaborative purposes to Denmark. ADIPOSIGN is run by four partners with …