Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.
A highly collaborative laboratory-based research group in the Clinical Research Division is recruiting an outstanding research technician to work as part of a team investigating new treatments for patients with acute myeloid leukemia (AML) primarily focused on improving existing, and developing novel, antibody-based immunotherapies, and rendering them safer for clinical application. Current projects include preclinical drug development/testing (in part with academic and industry partners), studies on mechanisms of action and resistance of antibody-based therapeutics and identification of strategies to overcome these limitations, and development of approaches to protect normal tissues from the toxicities of AML-targeted therapies (e.g. via use of genome editing.)
The newly hired research technician will work under the direction of the Principal Investigator and senior laboratory personnel and will be involved in the following techniques/duties:
- Generation of recombinant antibodies and other protein therapeutics via transient and permanent expression systems
- Conduct of immunization strategies to raise new antibodies
- Generation of engineered/gene-edited human leukemia cells
- Tissue culture of mammalian cell lines and patient-derived primary human cells
- Antibody drug conjugate (ADC) cytotoxicity, antibody-dependent cellular cytotoxicity, T-cell and NK-cell cytotoxicity assays
- Flow cytometry-based immunophenotyping, FACS isolation of mammalian cells
- Purification, cloning, and manipulation of RNA, cDNA and genomic DNA
- PCR and RT-PCR, including quantitative assays using qPCR
- Lentiviral vector modification, lentiviral particle preps and viral transduction
- Protein gels, immunoprecipitation, western blotting, immunofluorescence microscopy
- General laboratory duties and maintenance of laboratory equipment
To be successful in this position the applicant must be: organized, independent, open to learning, and provide clear and concise communication. Comprehensive laboratory record keeping is mandatory, experience with statistical analysis and data presentation is desirable.
A Bachelor’s degree in a field of biology such as immunology, cell and molecular biology, genetics, biochemistry, pathology, bioinformatics or genome sciences with 0-2+ years of laboratory experience outside of coursework. Must have scientific knowledge in the area of study and basic laboratory skills.
Applicants must submit:
- Cover letter discussing your interest in this position
- Curriculum Vitae
- Contact information for three references
A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.
Our Commitment to Diversity
We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at email@example.com or by calling 206-667-4700.