We are seeking a highly motivated, independent researcher for a postdoctoral position in the Protein Analytical Chemistry Department at Genentech. This research will encompass the structural analysis of biotherapeutic proteins utilizing an emerging higher order structure (HOS) technique: Hydroxyl Radical Footprinting-Mass Spectrometry (HFR-MS). The selected candidate will play a key role in pioneering the advancement of HRF-MS in an industry setting. Potential applications include optimization of formulation development, comparability assessments, structure/function linkage, and epitope mapping. In addition, the candidate will be able drive their own ideas and collaborate across Genentech and Roche Global. This work will include a strong cross-functional collaboration with the multiple other Pharmaceutical Technical Development (PTD) and Genentech Early Research and Development (gRED) departments.
The successful candidate will be a recent PhD graduate in Biochemistry, Chemical Biology, Structural Biology or a related discipline. A strong publication record should provide evidence of productive, independent contributions in science. The applicant must have demonstrated expertise in protein characterization using LC-MS analysis in areas such as native MS, ion mobility MS, post-translational modifications, cell-based biomarkers, and/or bottom-up MS technologies (HRF-MS and/or Hydrogen/Deuterium Exchange). Prior experience with protein structure determinations and computational structural rendering is highly desirable. Applied applications of MS with cell-based systems is the most relevant skill set, but not a requirement. The successful candidate must be highly self-motivated, capable of working independently, have excellent oral and written communication skills, and enjoy working in a collaborative setting.
For information about the Postdoctoral Program at Genentech, please go to www.gene.com/careers/academic-programs/postdocs