We have an opening for a talented Postdoctoral Fellow to join the laboratory of Dr. Andrey Shaw in the Research Biology Department at Genentech. We are looking for candidates with expertise in signal transduction to study signaling pathways in the immune system and cancer, focusing on the role of T cell co-stimulation, the role of signaling scaffolds in MAPK pathway regulation and the role of biological condensates.
The qualified individual will possess a Ph.D. in Biochemistry, Cell Biology, Immunology or related field with a solid publication record that includes at least one first authored publication. Excellent communication and writing skills as well as a track record of working in highly collaborative environments is a must.
The successful candidate will have a strong scientific background that could include: experience in protein purification, protein characterization, enzymology and characterization of protein-protein interactions, experience in cellular experiments (tissue culture, IP western and mass spec, siRNA/CRISPR) experience studying the immune system using animal models and familiarity with flow cytometry, CYTOF, single cell RNA-Seq as well as bioinformatic skills.
More information about the Shaw Lab:
More information about the Genentech Postdoctoral Program:
Relevant Lab Publications:
- Holdorf AD, Green JM, Levin SD, Denny MF, Straus DB, Link V, Changelian PS Allen PM, Shaw AS. Proline residues in CD28 and the SH3 domain of Lck ar required for T cell co-stimulation. J Exp Med 1999;190:375-384
- Holdorf AD, Lee K-H, Burack WR, Allen PM, Shaw AS. Regulation of Lck activityby CD28 and CD4 in the immunological synapse. Nat Immun 2002;3:259-264
- Nguyen A, Burack WR, Stock JL, Kortum R, Chaika OV, Afkarian M, Muller WJ, Murphy KM, Morrison DK, Lewis RE, McNeish J, Shaw AS. Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Mol Cell Biol 2002;22:3035-3045
- Locasale JW, Shaw AS, Chakraborty AK. Scaffold proteins confer diverse regulatory properties to protein kinase cascades. Proc Natl Acad Sci USA 2007;104:13307-13312.
- Lin J, Harding A, Giurisato E, Shaw AS. KSR1 modulates the sensitivity of th MAPK pathway activation in T cells without altering fundamental system outputs. Mol Cell Biol. 2009;29:2082-2091.
- Hu J, Stites EC, Yu H, Germino EA, Meharena HS, Stork PJ, Kornev AP, Taylor SS, Shaw AS. Allosteric activation of functionally asymmetric RAF kinse dimers. Cell 2013;154:1036-1046.