*Applications may be reviewed on a rolling-basis and this posting could close before the deadline. Click here for information about the selection process.
EPA Office/Lab and Location: A research opportunity is available at the Environmental Protection Agency (EPA), Office of Research and Development (ORD), Center for Computational Toxicology and Exposure (CCTE), Chemical Characterization & Exposure Division (CCED) located in Research Triangle Park, North Carolina.
Research Project: This research project will use in vitro and in vivo methods to assess the bioavailability of metals and metalloids. The in vitro methods include the use of mammalian cell-based assays. The in vivo methods include the use of a mouse-based assay. The research participant will have the opportunity to become part of a multi-lab research team that collaborates in the metal/metalloid bioavailability project. This research project provides an opportunity for the research participant to gain experience and proficiency in many aspects of laboratory research. During this opportunity, the research participant will develop skills in mammalian cell culture, animal handling, necropsy, sample collection, tissue preparation, and the processing of tissues for chemical and biochemical analysis. The research participant will learn proper record keeping skills and receive instruction on experimental design, animal feeding studies and animal housing and husbandry. The research participant will gain experience collecting, processing, analyzing and managing scientific data.
Learning Objectives: With guidance from the mentor, the research participant may be involved in the following training activities.
- Handling and treating small laboratory animals (mice)
- Basic animal husbandry
- Necropsy and preparation of tissues for chemical and biochemical analyses (such as mass spectroscopy, neutron activation, spectral analysis, and enzymatic assays)
- Analytical chemistry techniques
- Mammalian cell culture
- Cell culture-based biological assays
- Record keeping
- Data processing and statistical analysis graphical presentation
- Evaluating scientific literature and toxicological databases for information relevant to the bioavailability of metals and metalloids
- Participating through guidance of mentor in a range of scientific efforts, performs tissue analysis, data analysis using computers, performs QA/QC evaluations and library search relevant scientific literature
Mentor(s): The mentor for this opportunity is Michael Hughes (email@example.com). If you have questions about the nature of the research please contact the mentor(s).
Anticipated Appointment Start Date: Summer 2021. All start dates are flexible and vary depending on numerous factors. Click here for detailed information about start dates.
Appointment Length: The appointment will initially be for one year and may be renewed up to three to four additional years upon EPA recommendation and subject to availability of funding.
Level of Participation: The appointment is full-time.
Participant Stipend: The participant will receive a monthly stipend commensurate with educational level and experience. Click here for detailed information about full-time stipends.
EPA Security Clearance: Completion of a successful background investigation by the Office of Personnel Management (OPM) is required for an applicant to be on-boarded at EPA.
ORISE Information: This program, administered by ORAU through its contract with the U.S. Department of Energy (DOE) to manage the Oak Ridge Institute for Science and Education (ORISE), was established through an interagency agreement between DOE and EPA. Participants do not become employees of EPA, DOE or the program administrator, and there are no employment-related benefits. Proof of health insurance is required for participation in this program. Health insurance can be obtained through ORISE.
Questions: Please see the FAQ section of our website. After reading, if you have additional questions about the application process please email ORISE.EPA.ORD@orau.org and include the reference code for this opportunity.